Table 1.
HLA versus Age at Diagnosis. The proportion of type 1 diabetes subjects diagnosed at age <8, age ≥8 to <16, and age ≥16 years within each HLA category is reported as number (N) and as odds ratio (OR). The OR is calculated for age groups within each HLA diplotype (i.e., the OR of DR3/DR4 patients being diagnosed under 8 years of age is 1.97 as compared to DR3/DR4 patients diagnosed over 8 years of age). Fisher’s exact test was used to determine if age at diagnosis was significantly different for each HLA type. †P < 0.05, ‡P < 0.01.
| Age at Diagnosis | DRX/DRX | DR3/DRX | DR4/DRX | DR3/DR3 | DR4/DR4 | DR3/DR4 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | (OR) | N | (OR) | N | (OR) | N | (OR) | N | (OR) | N | (OR) | |
| <8 | 15 | (0.59) | 24 | (1.06) | 39 | (0.97) | 10 | (0.62) | 6 | (0.44) | 56 | (1.97‡) |
| 8–16 | 30 | (0.86) | 33 | (0.84) | 62 | (1.07) | 29 | (2.54‡) | 15 | (0.85) | 60 | (0.84) |
| >16 | 18 | (2.47‡) | 13 | (1.24) | 18 | (0.92) | 2 | (0.25†) | 11 | (3.07‡) | 10 | (0.37‡) |