Table 2.
Renal and cardiovascular parameters at 52 weeks of life. Data are expressed as mean ± standard error of the mean. n = 8 for UNX d1, n = 7 for UNX d14, n = 8 for controls. P-values were obtained from Bonferroni’s post hoc-test following one-way ANOVA or Dunn’s test following Kruskal-Wallis test.
| control | UNX d1 | p-value UNX d1 vs control | UNX d14 | p-value UNX d14 vs control | p-value UNXd1 | |
|---|---|---|---|---|---|---|
| Body weight [g] | 761.2 ± 22.6 | 743.0 ± 27.6 | 0.93 | 775.3 ± 19.7 | 0.96 | 0.73 |
| Kidney weight [g] | 3.89 ± 0.15 | 3.49 ± 0.22 | 0.30 | 3.21 ± 0.10 | 0.03 | 0.81 |
| Relative kidney weight [%] | 0.51 ± 0.02 | 0.46 ± 0.01 | 0.22 | 0.41 ± 0.01 | 0.003 | 0.16 |
| Glomerular perimeter [µm] | 362.1 ± 7.5 | 413.0 ± 5.7 | 0.001 | 411.4 ± 11.3 | 0.002 | 0.99 |
| Glom. cell number [no/glom] | 43.7 ± 3.4 | 57.7 ± 5.4 | 0.08 | 50.3 ± 3.4 | 0.86 | 0.71 |
| PCNA-pos. glomerular cells [no/glom] | 0.15 ± 0.04 | 0.24 ± 0.04 | 0.65 | 0.19 ± 0.06 | >0.99 | >0.99 |
| Relative left ventricular weight [%] | 0.172 ± 0.006 | 0.19 ± 0.01 | 0.31 | 0.175 ± 0.004 | >0.99 | 0.52 |
| Mean arterial pressure [mmHg] | 118.8 ± 2.1 | 122.1 ± 4.2 | >0.99 | 117.1 ± 2.9 | >0.99 | >0.99 |
| Renin mRNA [fold change] | 1.00 ± 0.17 | 0.82 ± 0.14 | >0.99 | 0.95 ± 0.14 | >0.99 | >0.99 |
| Renin-pos. juxtaglomerular apparatus [%] | 4.29 ± 1.09 | 2.31 ± 0.52 | 0.21 | 3.16 ± 0.71 | 0.78 | >0.99 |
| Plasma renin activity [ng AI/ml/h] | 4.37 ± 0.75 | 2.26 ± 0.40 | 0.026 | 3.23 ± 0.20 | 0.44 | 0.64 |