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. 2018 Mar 14;9(3):402. doi: 10.1038/s41419-018-0434-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Validation of the efficiency of TRIP13 expression. The upper panel is signal intensity; the lower panel is the quantified results. The values indicate the mean ± standard deviation. p < 0.01. b–e The effects of TRIP13 gain of function on in vitro proliferation (b, c), migration (d), and invasion (e). TRIP13 up-regulation significantly increased cell proliferation, migration and invasion abilities. The values indicate the mean ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001