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. 2018 Mar 14;9(3):402. doi: 10.1038/s41419-018-0434-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Tumors in nude mice bearing HCT116 cells in different groups. The upper panel is TRIP13 overexpression and the negative control; the lower panel is TRIP13 knockdown and the negative control. Each group contains six mice. b Statistical analysis of tumor volume in different groups. The left panel shows the overexpression and control groups, and the right panel shows the knockdown and control groups. The values indicate the mean ± standard deviation. n = 6/group. **p < 0.01; ***p < 0.001. c Statistical analysis of tumor weight in different groups. The left panel shows the overexpression and control groups, and the right panel shows the knockdown and control groups. The values indicate the mean ± standard deviation. n = 6/group. ***p < 0.001. d Representative staining images of TRIP13 overexpressing tumors. The bars are as indicated. e Representative staining images of TRIP13 knockdown tumors. The bars are as indicated