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. 2018 Mar 14;8:4483. doi: 10.1038/s41598-018-22713-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sequence alignment of mammalian voltage-gated sodium channel isoforms with Na_vPaS, EeNa_v1.4 and human Ca_V1.1. (a) III-IV linker region and (b) C-terminal domain region aligned with Clustal Omega. Fully conserved residues are shaded. Known disease associated residues in Na_v1.5 are marked by boxes coloured according to their disease phenotype LQT3 (black), BrS (blue), or both (brown). The phosphorylation site in the III-IV linker is marked by an asterix⁵¹. Secondary structure has been annotated according to the DSSP calculations of Na_v1.2 (PDB ID 1BYY) and Na_v1.5 (PDB ID 4OVN) structures in the protein structure database.