Table 1.
COHORT 1 | ||||||||
---|---|---|---|---|---|---|---|---|
Female | ||||||||
Genotype | H2O2 | N | Mean (SD) | Median | 90% | Δ Mean % | Δ Median % | (p) |
Canton-S | 0 µM | 90 | 52 (15) | 56 | 69 | |||
10 µM | 90 | 61 (13) | 65 | 78 | 6.87 | 8.26 | 0.0036 | |
100 µM | 94 | 60 (14) | 65 | 76 | 6.40 | 8.02 | 0.0047 | |
Oregon-R | 0 µM | 121 | 60 (15) | 62 | 79 | |||
10 µM | 120 | 77 (17) | 82 | 100 | 17.02 | 19.46 | 3.02E−13 | |
100 µM | 120 | 74 (14) | 75 | 96 | 15.51 | 16.18 | 2.18E−13 | |
w[1118] | 0 µM | 96 | 50 (13) | 50 | 70 | |||
10 µM | 120 | 62 (13) | 64 | 72 | 10.72 | 11.11 | 0.0002 | |
100 µM | 94 | 64 (14) | 64 | 72 | 12.28 | 11.11 | 0.0001 |
Male | ||||||||
---|---|---|---|---|---|---|---|---|
Genotype | H2O2 | N | Mean (SD) | Median | 90% | Δ Mean % | Δ Median % | (p) |
Canton-S | 0 µM | 81 | 51 (15) | 55 | 67 | |||
10 µM | 80 | 51 (15) | 55 | 67 | −0.4108 | 0.000 | 0.9272 | |
100 µM | 83 | 52 (15) | 55 | 67 | −0.4643 | 0.000 | 0.9491 | |
Oregon-R | 0 µM | 80 | 50 (10) | 54 | 61 | |||
10 µM | 80 | 50 (10) | 54 | 60 | −0.887 | 0.000 | 0.7749 | |
100 µM | 78 | 50 | 54 | 58 | −0.473 | 0.000 | 0.9441 | |
w[1118] | 0 µM | 119 | 46 (13) | 47 | 64 | |||
10 µM | 102 | 46 (14) | 47 | 64 | −0.514 | 0.000 | 0.7111 | |
100 µM | 139 | 46 (13) | 47 | 64 | −0.188 | 0.000 | 0.8486 |
COHORT 2 | ||||||||
---|---|---|---|---|---|---|---|---|
Female | ||||||||
Genotype | H2O2 | N | Mean (SD) | Median | 90% | Δ Mean % | Δ Median % | (p) |
Canton-S | 0 µM | 95 | 49 (15) | 52 | 63 | |||
10 µM | 94 | 59 (13) | 59 | 76 | 8.65 | 6.31 | 0.0031 | |
100 µM | 95 | 62 (13) | 61 | 78 | 9.74 | 7.64 | 0.0025 | |
Oregon-R | 0 µM | 80 | 70 (16) | 73 | 84 | |||
10 µM | 81 | 78 (10) | 82 | 98 | 8.041 | 7.775 | 3.92E−05 | |
100 µM | 80 | 78 (11) | 82 | 94 | 7.667 | 7.531 | 4.31E−05 | |
w[1118] | 0 µM | 124 | 41 (16) | 42 | 54 | |||
10 µM | 123 | 56 (17) | 55 | 72 | 13.99 | 12.61 | 1.56E−04 | |
100 µM | 125 | 58 (17) | 59 | 72 | 14.36 | 15.83 | 2.96E−04 |
Male | ||||||||
---|---|---|---|---|---|---|---|---|
Genotype | H2O2 | N | Mean (SD) | Median | 90% | Δ Mean % | Δ Median % | (p) |
Canton-S | 0 µM | 84 | 52 (16) | 52 | 62 | |||
10 µM | 85 | 49 (17) | 52 | 65 | −1.295 | 0.000 | 0.7179 | |
100 µM | 85 | 51 (16) | 52 | 62 | −0.238 | 0.000 | 0.9278 | |
Oregon-R | 0 µM | 60 | 53 (9) | 54 | 65 | |||
10 µM | 60 | 51 (9) | 54 | 60 | −0.749 | 0.000 | 0.6582 | |
100 µM | 59 | 48 (10) | 54 | 56 | −2.213 | 0.000 | 0.3709 | |
w[1118] | 0 µM | 147 | 55 (13) | 58 | 70 | |||
10 µM | 136 | 54 (13) | 58 | 70 | −1.071 | 0.000 | 0.3997 | |
100 µM | 141 | 55 (12) | 58 | 70 | −0.174 | 0.000 | 0.7161 |