Fig. 2.

Model 2 fit for polygenic risk score predictions on positive and negative symptom dimensions. The plots show model 2 results of 13 analyses based on SNP set without linkage disequilibrium. For each P_T, SNPs are selected if significant at that threshold and coefficients and effect sizes estimated. Values above each bar are unadjusted p-values of phenotype from regression analyses. For 2A, the best fit PRS for negative symptoms is at P_T of 0.1 and explains roughly 1.2% of the variance. For 2B, the best fit PRS for positive symptoms is at P_T of 0.01 and roughly explains 0.7% of the variance.