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. 2017 Dec 21;5(3):299–318. doi: 10.1016/j.jcmgh.2017.12.005

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Support data of inflammation and fibrosis. (A) Box plots of fecal lipocalin-2 level quantified using an enzyme-linked immunosorbent assay kit. Fecal lipocalin (Lcn-2) levels were measured before and 5 or 6 weeks after TNBS administration, in WT mouse and TRPA1-/- mouse before TNBS treatment. TNBS 5 weeks (just before last treatment), TNBS 6 weeks, respectively. By using 2-way analysis of variance with TNBS treatment and TRPA1 knockout as 2 independent variables, only the former turned out to be a statistically significant factor (∗P < .05, n = 6–8). (B) Severe inflammation and fibrosis in TNBS-treated TRPA1–CRISPR knockout mouse. H&E-stained and MT-stained TRPA1^-/- CRISPR mouse intestine. (C) Histologic fibrosis score from 0 (no fibrosis) to 3 (severe fibrosis) of WT and TRPA1-/- mouse before last TNBS challenge (TNBS 5 weeks) was shown in dot plot graph (n = 8). Values are means ± SD.