Table 3.

Increased Liver Injury With Fast Food Diet, but Not With Fpn1 Deletion

	Control diet			Fast food diet
	Flox	FKO	P	Flox	FKO	P
NAS (0–8)	4 (0–6)	2 (0–5)	NS	6 (5–7)	6 (5–7)	NS
Steatosis (0–3)	2.5 (0–3)	1.5 (0–3)	NS	3 (3–3)	3 (3–3)	NS
Lobular inflammation (0–3)	0 (0–1)	0 (0–1)	NS	1 (0–2)	1 (0–2)	NS
Ballooning (0–2)	1.5 (0–2)	0.5 (0–2)	NS	2 (2–2)	2 (2–2)	NS
Fibrosis (0–4)	0 (0–1)	0 (0–2)	NS	2 (1–2)	2 (2–2)	NS

NOTE. Median score (range) for NAS (score, 0–8), macrovesicular steatosis (grade, 0–3), lobular inflammation (grade, 0–3), ballooning (grade, 0–2), fibrosis (grade, 0–4). P value was the result of Mann–Whitney tests comparing genotypes for each diet (n = 8–12 per group).

NAS, NAFLD activity score.