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. Author manuscript; available in PMC: 2018 Mar 15.
Published in final edited form as: J Med Chem. 2014 Aug 4;57(15):6342–6353. doi: 10.1021/jm4018042

Figure 6.

Figure 6

Treatment with compound 12 reduces the volume of human breast cancer (SUM149) xenograft tumors. (A) Mice bearing SUM149 tumors were administered compound 12 via ip 10 and 30 mg/kg every other day. Tumor sizes were measured every other day and converted into volumes by L × w × w/2, plotted against days of treatment. Data are present as the mean ± SEM (n = 5, P < 0.05). (B) Western blot of day 5 for compound 12 treated SUM149 tumors were evaluated for PTPN6, STAT3, and pSTAT3. GAPDH was used as a control. (C) Densitometry of PTPN6 with statistical significance using a one tailed t test (* P < 0.005).