The cohort studies checklist consisted of 4 main items: selection bias, performance bias, attrition bias and detection bias. Based on the score of their respective subitems, the main items were scored as low, unclear and high risk of bias. For each main item, a low response indicated that the study was designed and conducted in a manner that minimized the risk of bias for that item. An unclear response was given when the information required to score an item was not reported or was not reported clearly. A priori, was decided that studies were excluded if more than 2 out of 4 main items would be scored as high risk of bias on the basis of low methodological quality.