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. 2018 Jan 8;5(3):399–413. doi: 10.1016/j.jcmgh.2018.01.003

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

HFD-plus-multiple binges of ethanol challenge induces liver fibrosis. (A–C) Male C57BL/6J mice were fed an HFD for 3 months, followed by 8 gavages of 5 g/kg ethanol (twice a week) (HFD+mB group), or isocaloric dextrin-maltose (HFD group), while continuing on HFD for an additional month. (A) Representative images are shown. (B and C) Serum ALT and AST levels, liver tissue collagen content, percentage of Sirius Red–positive area, as well as body weight were examined and are shown. (D) Liver tissues from different groups were subject to quantitative RT-PCR analyses of Ly6g mRNA. N = 6–7 in each group. *P < .05, **P < .01, ***P < .001.