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. 2018 Jan 8;5(3):399–413. doi: 10.1016/j.jcmgh.2018.01.003

Figure 5.

Figure 5

Icam-1–deficient mice have reduced hepatic neutrophil infiltration, liver injury, and fibrosis induced by HFD+1B ethanol feeding. WT and Icam-1 KO mice were subject to HFD+1B ethanol challenge, and mice were euthanized 9 hours after gavage. (A) Liver sections were stained with MPO, Sirius Red, and Masson Trichrome. Images represent 1 of 5 fields in each group. Arrows indicate MPO+ cells. (B) Quantitative RT-PCR analyses of neutrophil marker gene Ly6g. (C) Serum ALT levels were analyzed. (D) Percentage of Sirius Red–positive area and body weight were analyzed. (E) Quantitative RT-PCR analyses of fibrosis-related genes. (B–E) N = 5–7 in each group. *P < .05.