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. 2018 Jan 31;9:57–69. doi: 10.1016/j.omtm.2018.01.004

Figure 4.

Figure 4

Expression and Tissue Specificity of LCO, MCO, and NoCo Designs

(A and B) HepG2 cells were transfected with (A) ET3-LCO-, ET3-MCO-, and ET3-MCO-encoding plasmids and (B) HSQ-LCO-, HSQ-MCO-, and HSQ-NoCo-encoding plasmids. fVIII activity in the conditioned media was measured 48 hr after transfection. In (A), *p = 0.011 and **p = 0.006, and in (B), *p = 0.006 and **p = 0.005 by one-way ANOVA and the Holm-Sidak method. (C and D) BHK cells were transfected with (C) ET3-LCO-, ET3-MCO-, and ET3-MCO-encoding plasmids and (D) HSQ-LCO-, HSQ-MCO-, or HSQ-NoCo-encoding plasmids. In (C), *p < 0.001, and in (D), *p = 0.007 and **p = 0.004 by one-way ANOVA and the Holm-Sidak method. Data are presented as the mean ± sample SD.