Figure 8.

Proteomic analysis reveals a gene signature associated with tumor aggressiveness in BT-549^rDOX²⁰ cells

(A) Volcano-Plot showing the protein ratios (in log2) as a function of the –log p-value of label-free quantification proteomic-data from BT-549^rDOX²⁰ cells compared to BT-459Par. A total of 4906 proteins were quantified, of those 271 (red dots) and 307 (blue dots) were significantly reduced and increased, respectively. (B and C) Bioinformatic cluster analysis using String (string-db.org; [41]) was performed. (B) Shows all KEGG pathways that are overrepresented among reduced (red) or increased protein groups (blue). (C) Shows the 10 highest ranking Gene Ontology (GO) biological processes (GO:BP) that are overrepresented among proteins with significantly reduced (red) or increased amount (blue).