Table 2.
The 10 Highest Ranking Proteins are Listed Along with the NCBI Gene ID, the Log2 Ratio of BT-549rDOX20 Over BT-549Par and the –Log P Value, as Well as a Brief Summary of the Known Function of These Proteins in Cancer
| Official gene name | Gene-ID | log2 ratio | –log p value | Function |
|---|---|---|---|---|
| ANPEP | 290 | -8.567 | 3.364 | Silenced in prostate cancer [53] |
| LRP1 | 4035 | -7.233 | 3.030 | Cancer cell survival and metastasis [54] |
| DCLK1 | 9201 | -6.092 | 3.274 | Associated with favorable prognosis in breast cancer [55] |
| COL5A1 | 1289 | -5.178 | 4.235 | Marker gene for TNBC classification [56] |
| OAS2 | 4939 | -4.594 | 2.313 | Higher expression in relapsed tumors [57] |
| STEAP3 | 55240 | -4.294 | 2.433 | Part of a metastasis gene signature [58] |
| PLA2G4A | 5321 | -4.190 | 2.565 | Associated with adverse prognosis [59] |
| ITPR1 | 3708 | -3.948 | 3.958 | Breast cancer susceptibility locus [60],[61] |
| SERPINB5 | 5268 | -3.900 | 3.477 | Tumor suppressor in breast cancer [62] |
| DTX3L | 151636 | -3.881 | 2.156 | Associated with overall survival and autophagy signature [63] |
| Official gene name | Gene-ID | log2 ratio | –log p value | Known relevance for breast cancer |
|---|---|---|---|---|
| EDIL3 | 10085 | 6.668 | 3.885 | Cell invasion and metastasis [64] |
| ALDH5A1 | 7915 | 5.188 | 2.805 | Stem-like phenotype [65]; detoxifaction [66] |
| MYO6 | 4646 | 4.908 | 3.694 | Oncogenic in breast cancer [67] |
| FHL2 | 2274 | 4.317 | 3.774 | Oncogenesis and tumor progression [68], [69] |
| CROT | 54677 | 4.242 | 2.945 | Correlates with drug resistance [70] |
| LMCD1 | 29995 | 4.101 | 2.864 | Involved in tumor recurrence [71] |
| GNG11 | 2791 | 4.049 | 3.740 | Cell migration and metastasis [72] |
| KYNU | 8942 | 3.908 | 1.968 | Metastasis [73] |
| CUX1 | 1523 | 3.804 | 4.027 | Migration, invasion and apoptosis-resistance [74], [75] |
| TAGLN | 6876 | 3.349 | 2.201 | Epithelial mesenchymal transition [76] |