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. 2017 Dec 13;5(3):367–398. doi: 10.1016/j.jcmgh.2017.11.016

Figure 4.

Figure 4

TBE-31 improves insulin sensitivity in HFFr-fed Nrf2+/+mice. (A) Insulin sensitivity (ie, ITT) (and as % change in blood glucose) in Nrf2+/+ mice after 22 weeks RC- (white circle) or HF55Fr/HF30Fr (HFFr)- (white square) feeding. (B) Glucose tolerance (ie, GTT, with AUC) in Nrf2+/+ mice after 23 weeks RC (white circle) or HFFr (white square) feeding. (C) Insulin sensitivity (ITT) (and as % change in blood glucose) in Nrf2+/+ mice after 28 weeks HFFr diet, and 4 weeks DMSO (white square) or TBE-31 (black square). (D) Glucose tolerance (GTT, with AUC) in Nrf2+/+ mice after 29 weeks HFFr diet and 5 weeks DMSO (white square) or TBE-31 (black square). (E) Pyruvate tolerance (PTT) (and as % change in blood glucose, with AUC) in Nrf2+/+ mice after 29.5 weeks RC diet or HFFr diet, and 5 weeks DMSO (white square) or TBE-31 (black square). In A and B, n = 20–24 mice/group: in C–E, n = 6–8 mice/group. White bars, DMSO treated; black bars, TBE-31 treated. Data are means ± SEM: ∗,$P < .05; ∗∗P < .01; ∗∗∗P < .001. AUC, area under the curve.