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. 2017 Dec 13;5(3):367–398. doi: 10.1016/j.jcmgh.2017.11.016

Figure 7.

Figure 7

TBE-31 decreases the abundance of triglycerides and cholesterol in the livers of HFFr-fed Nrf2+/+mice. Lipids and mRNA for Adrp were measured in livers from mice in Study 1. Triglyceride (A) and cholesterol (B) in livers from mice on the RC diet and mice on the HF55Fr/HF30Fr (HFFr) diet. (C) qRT-PCR for Adrp. White bars, DMSO-treated; black bars, TBE-31−treated (n = 8–12 mice per group). Results are means ± SEM. Significant increases in triglyceride or cholesterol levels, relative to those in livers from RC-fed Nrf2+/+ mice, are indicated by: *P < .05; ***P < .001. Significant decreases in hepatic triglyceride or cholesterol levels, or mRNA for Adrp, resulting from treatment with TBE-31, relative to HFFr-fed Nrf2+/+ mice, are indicated by: $P < .05.