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. 2017 Dec 13;5(3):367–398. doi: 10.1016/j.jcmgh.2017.11.016

Figure 8.

Figure 8

TBE-31 stimulates lipid catabolism and suppresses lipogenic transcription factors. On completion of Study 1, livers were removed from Nrf2+/+ mice and portions examined for expression of lipid-associated genes and protein analyses of the transcription factor Srebp-1c. (A) qRT-PCR for Acox2, Ces1g, and Acot7, (B) qRT-PCR for PPARα, Cpt1a, and Scad, and (C) qRT-PCR for Srebf1, Mlxipl, Lxrα, and Xbp1s (n = 8–12 mice per group). (D) A representative Srebp-1c immunoblot of cytoplasmic (cSrebp-1c) and nuclear (nSrebp-1c) protein (left side), with densitometric scans of blots (right side) (n = 6 biologic replicates). White bars, DMSO; black bars, TBE-31. Data are means ± SEM. Significant increases in gene expression or protein abundance, relative to that in livers from RC-fed Nrf2+/+ mice, are indicated by: *P < .05; **P < .01; ***P < .001. Significant decreases in gene expression or protein abundance, relative to that in livers from RC-fed Nrf2+/+ mice, are indicated by: $P < .05; $$P < .05.