Figure 2.

NHERF1 pathways. In the middle part (A), in physiological conditions NHERF1 phosphorylates Na⁺/H⁺ exchangers (NHEs) affecting their activity and microenvironment acidification. On the left (B), NHERF1 acts as an oncosuppressor protein negative regulating the proliferative activity of EGFR pathway, when it is localized at the plasma membrane. On the right (C), NHERF1 appears as oncogene, in fact it imports β-catenin into the nucleus to form a bridge complex with the trancription factor TCF. This complex activates oncogenes transcription such as cMyc, CD1 etc.