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Representative images of NHERF1 immunoreactivity and localization in metastatic CRC. (A) NHERF1 staining is present mostly in membrane of DNT mucosa; (B) in the cytoplasmic and nuclear of SNT and (C) in ADN; (D) over-expression of cytoplasmic and nuclear NHERF1 is present in T, (E) LnM and (F) LM. DNT: distant non-neoplastic tissue, SNT: surrounding non-neoplastic tissue, ADN: adenoma, T: primary tumor, LnM: synchronous lymph node metastasis, LM: liver metastasis.
