Table 3.
(A) Multivariate regression analysis of miRNAs for the presence of prediabetes and T2D. (B) Multivariate regression analysis of miRNAs for the development of T2D.
| Prediabetes | T2D | |||||
|---|---|---|---|---|---|---|
| (A) | ||||||
| miR-375 | ||||||
| Models | OR | 95% CI | p value | OR | 95% CI | p value |
| Model 1 | 1.12 | 1.022–1.168 | 0.009 | 1.123 | 1.049–1.201 | 0.001 |
| Model 2 | 1.11 | 1.023–1.174 | 0.009 | 1.134 | 1.056–1.219 | 0.001 |
| Model 3 | 1.12 | 1.012–1.26 | 0.023 | 1.125 | 1.045–1.212 | 0.022 |
| Model 4 | 1.13 | 1.012–1.168 | 0.022 | 1.126 | 1.045–1.214 | 0.002 |
| miR-9 | ||||||
| Model 1 | 1.11 | 1.005–1.147 | 0.035 | 1.080 | 1.011–1.153 | 0.022 |
| Model 2 | 1.12 | 1.010–1.157 | 0.024 | 1.082 | 1.012–1.157 | 0.021 |
| Model 3 | 1.1 | 1.002–1.150 | 0.044 | 1.078 | 1.007–1.154 | 0.032 |
| Model 4 | 1.1 | 1.006–1.161 | 0.035 | 1.081 | 1.007–1.159 | 0.031 |
| (B) | ||||||
| miR-375 | ||||||
| Models | - | OR | 95% CI | p value | ||
| Model 1 | - | 1.12 | 0.999–1.157 | 0.05 | ||
| Model 2 | - | 1.141 | 1.001–1.528 | 0.001 | ||
| Model 3 | - | 1.143 | 1.001–1.483 | 0.044 | ||
| Model 4 | - | 1.151 | 1.006–1.197 | 0.025 | ||
| miR-9 | ||||||
| Model 1 | - | 1.006 | 0.982–1.030 | 0.64 | ||
| Model 2 | - | 1.001 | 0.976–1.026 | 0.954 | ||
| Model 3 | - | 1.003 | 0.975–1.030 | 0.85 | ||
| Model 4 | - | 0.972 | 0.916–1.031 | 0.33 | ||
T2D, type 2 diabetes; OR, odds ratio; CI, confidence interval. (A) The reference category was the non-diabetic healthy control group. Model 1: crude; Model 2: included age and sex. Model 3: included age, sex, BMI and mean blood pressure. Model 4: included age, sex, BMI, mean blood pressure, total cholesterol, triglyceride and LDL. (B) The reference category was the prediabetes group. Model 1: crude. Model 2: included age and sex. Model 3: included age, sex, BMI, mean blood pressure and HbA1c. Model 4: included age, sex, BMI, mean blood pressure, HbA1c, total cholesterol, triglyceride and LDL.