Table 2.
Invasive prenatal diagnoses of β-thalassemia in Sardinia: 8564 in 40 years (1977–2017).
| Techniques | No. | Years | Gestational Age (Weeks) | Failure No. | Fetal loss (%) | Misdiagnosis |
|---|---|---|---|---|---|---|
| Placentacentesis | 981 | 1977–1983 | 18–24 | 10 | 5.2 | 2 |
| Fetoscopy | 67 | 1983–1985 | 18–24 | 2 | 5.6 | - |
| Cordocentesis | 120 | 1984–1985 | 18–24 | 1 | 2.1 | - |
| Hepatic vein puncture | 3 | 1984–1986 | 18–24 | - | - | - |
| Cardiocentesis | 3 | 1984–1986 | 18–24 | - | - | - |
| Amniocentesis | 203 | 1982–1983 | 16–18 | 6 2 | 2.6 | - |
| Trans-cervical CVS 1 | 572 | 1983–1986 | 9–13 | 1 2 | 4.2 | 1 |
| Trans-abdominal CVS 1 | 6615 | 1985–1917 | 6–24 | - | 0.6 | - |
1 CVS, chorionic villus sampling; 2 Due to limited amount of DNA at sampling.