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. 2018 Mar 6;14:560–575. doi: 10.3762/bjoc.14.43

Table 2.

Formation and substrate scope of phenolic Mannich bases.

graphic file with name Beilstein_J_Org_Chem-14-560-i001.jpg
entry R1 R2 graphic file with name Beilstein_J_Org_Chem-14-560-i002.jpg product reference
1 4-Me, 4-COOMe Ph, 4-MeOPh, 4-NO2Ph, 3-CF3Ph, 2-All-O-Ph graphic file with name Beilstein_J_Org_Chem-14-560-i003.jpg 8a–i [63]
2 H, 2-Me, 3,5-(OH)2-2,4-(CHO)2, 3,5-(OH)2-2,4-Ac2, 3,5-(OH)2-2,4-dipropanoyl, 3,5-(OH)2-2,4-diisobutanoyl, 3,5-(OH)2-2,4-dibutanoyl H graphic file with name Beilstein_J_Org_Chem-14-560-i004.jpg 9a–t [64–65]
3 3-Cl, 2-NO2, 4-OMe, 4-NO2, 4-Cl, 2,4-Cl2 4-BrPh, 4-NO2Ph, 4-ClPh, 4-OMePh, 2,3-Me2Ph, 4-t-BuPh graphic file with name Beilstein_J_Org_Chem-14-560-i005.jpg 10a–m [66]