Table 4.
Effect of low-dose Ang II combined with regular or 2% high salt diet on renal EO (µg/kg) (top panel); and effect of central MR-ENaC-AT1R blockade on renal cortex, medulla and papilla EO (µg/kg) (bottom panel)
| Regular salt | High salt | Regular salt + Ang II | High salt + Ang II | |
|---|---|---|---|---|
| (n = 6) | (n = 6) | (n = 8) | (n = 8) | |
| Kidney | 1.3 ± 0.1 | 1.3 ± 0.1 | 3.3 ± 0.5* | 4.0 ± 0.5** |
| High salt + Ang II | ||||
| + | + | + | + | |
| Veh (n = 11) | MR inh (n = 9) | Ben (n = 6) | Los (n = 4) | |
| Renal cortex | 2.2 ± 0.4 | 3.5 ± 1.1 | 4.0 ± 1.2 | Δ |
| Renal medulla | 39.5 ± 9.2*** | 16.5 ± 4.6 | 6.0 ± 0.9 | 16.6 ± 8.9 |
| Renal papilla | 7.6 ± 1.3 | 6.2 ± 1.4 | 4.2 ± 1.9 | 6.6 ± 1.6 |
Values are means ± SE.
Lower panel: Values are for vehicles (Veh), combined eplerenone and spironolactone (MR inh), benzamil (Ben) and losartan (Los). Δ: sample size is too small and data are not included.
*
P < 0.05 vs. regular salt.
**
P < 0.05 vs. high salt.
***
P < 0.05 vs. others.