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Mathematical models of both atrial and sinoatrial cells show an arrhythmic contribution of the T78M cav-3. Atrial (top) and sinoatrial (bottom) action potentials generated using the Grandi-Bers human atrial cell model19 and the Severi-DiFrancesco rabbit sinoatrial cell model,20,21 respectively. Thin line, basal conditions (WT); thick line, after insertion of the T78M cav-3-dependent alterations.
