SS-induced EC NO production in rat venules. (A) Both plasma and blood perfused vessels show SS-dependent increases in EC NO production, and the application of NOS inhibitor, L-NMMA, abolished such effect. (B) Summary data show SS-dependent NO production rate in the absence (n = 5 per group) and presence of L-NMMA (n = 4). ***P ≤ 0.0005, **P < 0.005, *P < 0.05. Solid line link: one-way ANOVA with post-hoc Tukey to compare perfusion groups with the same SS. Dotted line link: paired student’s t-test for paired studies conducted in each vessel.