Skip to main content
. 2017 May 4;113(11):1351–1363. doi: 10.1093/cvr/cvx089

Figure 3.

Figure 3

LPA-induced VICs mineralization relies on the NF-κB pathway. (A and B) NF-κB reporter assay showing increased NF-κB activity in response to LPA (n = 4) (A) and its inhibition by BAY11-7085 (n = 6) (B). (C) BAY11-7085 prevents LPA-induced mineralization (n = 6). (D–F) NF-κB reporter assay; Y27632 (n = 6) (D) and RhoA N19 (n = 6) (E) inhibits and RhoA L63 (n = 6) (F) mimics LPA effect on NF-κB activity. (G and H) IL-6 mRNA measurements in response to LPA, Y27632 (n = 6) (G) and siLPAR1 (n = 6) (H) decreases LPA-induced IL-6 rise. Values are mean ± SEM. LPA: 10 µM, BAY11-7085: 5 µM, Y27632: 5 µM; * P < 0.05.