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. 2017 May 4;113(11):1351–1363. doi: 10.1093/cvr/cvx089

Figure 4.

Figure 4

LPA-mediated activation of the NF-κB pathway promotes BMP2 expression. (A and B) LPA increases BMP2 promoter activity (n = 4) (A) and BMP2 protein level (n = 6) (B). (C) RhoA N19 inhibits LPA-induced BMP2 promoter activity (n = 6). (D) Y27632 (n = 6) and BAY11-7085 (n = 6) abrogates LPA-mediated rise in BMP2 mRNA. (E and F) p65 is required for LPA regulation of BMP2 level (n = 6) (E) and mineralization (n = 6) (F). Values are mean ± SEM. LPA: 10 µM, Y27632: 5 µM, BAY11-7085; * P < 0.05.