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. 2017 May 4;113(11):1351–1363. doi: 10.1093/cvr/cvx089

Figure 7.

Figure 7

Role of the ATX-LPAR1 pathway in vivo. (A) LPA is increased in IGFII mice serum (n = 10). (B–C) LPA level correlates with blood plasma ATX activity (B) and cholesterol level (C) (n = 10). (D–E) Lpar1 is elevated in IGFII mice (D) and it correlates with Bmp2 level (E) (n = 8). (F) Outline of the animal protocol. (G and H) Transaortic velocities (V2) were increased in mice receiving vehicle (G) (n = 12) while they were stable in mice receiving Ki16425 (H) (n = 11). (I) ΔV2 was significantly higher in mice receiving vehicle compared with Ki16425 (n = 23). (J) ΔLVFS was significantly lower in mice receiving vehicle compared with Ki16425 (n = 23). (K) Hydroxyapatite was more abundant in leaflets of mice receiving vehicle compared with Ki16425 (n = 13), scale bar 200 µM. Values are mean ± SEM. Ki16425: 5 mg/kg/day.