Table 2.
lncRNAs in SMC fate and functionality
| lncRNA | Regulation | Related targets and factors | Role and function in SMC dynamics | References |
|---|---|---|---|---|
| ANRIL | ↓↑ | CDKN2A, CDKN2B, DAB2IP, LRP1, LRPR, CNTN3 | Proliferation | 10,109–112 |
| RNCR3 | ↑ | KLF2, miR-185 | Proliferation | 108 |
| H19 | ↑ | miR-675, IGF2, let7, p53, NOTCH1, miR-106a, MYC, miR-19b, SOX6 | Differentiation and proliferation | 64–76 |
| lnc-362 | ↑ | miR-221/222 | Host-gene for miRNAs, proliferation | 105 |
| SENCR | ↑ | FLI1 | Migration and proliferation | 77,78 |
| Lnc-GAS5 | ↓ | ANXA2 | Differentiation, proliferation, and migration | 106,107 |
| Lnc-MEG3 | – | p53, MMP2, IFN-γ | Proliferation, migration, and apoptosis | 137,138 |
| MYOSLID | – | MYOCD, MRTF-A, TGF-β (SMAD) | Differentiation and proliferation | 79 |
| HIF1α-AS1 | ↑ | HIF1A, BRG1 | Apoptosis and proliferation | 45,135,136 |
| HAS-AS1 | ↑ | HAS2 | ECM remodelling and deposition | 122 |
| lincRNA-p21 | ↑ | p53, p300 | Apoptosis | 133,134 |
lncRNAs and their regulation (up- or down; if applicable) under vascular disease relevant conditions and stimuli. Further depicted in the table are the associated up- and downstream targets, their main effect in SMC dynamics, and the respective references. Abbreviations of lncRNAs and associated mediators/genes are explained in the running text.