Figure 5.

Platelet ROCK2 deficiency does not contribute to non-thrombotic stroke, vascular remodeling, and atherosclerosis. (A) Coronal brain sections stained with 2,3,5-triphenyltetrazolium chloride (TTC) from control (PF4-Cre) and ROCK2^Plt−/− mice following middle cerebral artery occlusion (MCAO) (n = 9–6, left panel), and quantification of cerebral infarct volume from TTC-stained brain section (right panel, scale bar 5 mm). (B) H&E staining of common carotid artery 15 days following ligation in PF4-Cre and ROCK2^Plt−/− mice (n = 5). (C) Oil Red-O staining and quantification of atherosclerotic lesions of en face aorta and (D) aortic sinus areas cross sections in PF4 BMT and ROCK2^Plt−/− BMT mice after 16 weeks of atherogenic diet (n = 10).