Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Feb 21;113(8):984–995. doi: 10.1093/cvr/cvx033

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author 2017. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Inhibition of RyR channels by H⁺ ions can account for regional Ca²⁺ wave inhibition during pH_i heterogeneity. (Ai) 3D surface plots of Ca²⁺ sparks (recorded in linescan mode) illustrate a uniform distribution under resting conditions. Imposed pH_i gradient inhibits spark events in acidic (acetate, A) microdomain. (Aii) Sparks were inhibited in the acidic microdomain in the presence (n = 9 cells/2 animals) and absence (n = 5 cells/1 animal) of NHE1 activity. (Bi) Top panel represents dual microperfusion apparatus. Linescan of a Ca²⁺ wave during regional superfusion with tetracaine. (Bii) Wave initiation and propagation were suppressed in the tetracaine-exposed microdomain (remote effect is not significant; n = 12 cells/3 animals, P = 0.1175). Paired t-tests.