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. 2017 Aug 31;113(14):1732–1742. doi: 10.1093/cvr/cvx166

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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com.

PMC Copyright notice

Wholemount ISH of Nkx2.5^Cre/+; Hand1^A126FS/+ mutant embryos reveals altered cardiac gene expression during heart formation. E11.5 Nkx2.5^+/+; Hand1^SF-A126FS/+ control (A, C, E, G) and Nkx2.5^Cre/+; Hand1^A126FS/+mutant (B, D, F, H) embryos hybridized to the indicated riboprobes. Wnt11 marks OFT tissue (white bars; A and B). Tbx5 is an LV chamber maker. Tbx5 expression appears more homogeneous in Nkx2.5^Cre/+; Hand1^A126FS/+mutants when compared with controls (white arrowhead; C and D). Dkk3 marks the IVS and ventricular chambers. Dkk3 expression appears more robust in Nkx2.5^Cre/+; Hand1^A126FS/+mutants (white arrowhead; E and F). Cited1 appears unchanged between control and Nkx2.5^Cre/+; Hand1^A126FS/+mutants (G and H). Data represent an example of each genotype. Eight embryos per genotype were examined. Scale bars 150 μm.