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. 2018 Feb 6;9(2):74. doi: 10.3390/genes9020074

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Synthetic strategy for the preparation of SQ-siRNA NPs. (B) MTT assay at several concentrations of SQ-siRNA NPs and incubation times. (C) Reduction of RET/PTC1 mRNA expression in vitro after incubating siRNA RET/PTC1 (60 nM) in the presence of lipofectamine. (D) Effect of SQ-siRNA NPs in reducing the tumour growth after 20 days of treatment. (E) Reduction of RET/PTC21 mRNA expression measured by qRT-PCR after incubation with SQ-siRNA NPs in vivo. The silence activity mediated by SQ-siRNA NPs was significant (*) when compared to untreated cells according to ANOVA analysis. A scrambled siRNA sequence (control siRNA) was used in order to determine the specificity of the gene silencing process. Adapted with permission from ref. [118]. Copyright 2011, American Chemical Society.