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. 2018 Feb 6;9(2):74. doi: 10.3390/genes9020074

Figure 5.

Figure 5

(A) Synthetic strategy for the preparation of L-serine-based siRNA conjugates (green) modified with docosahexaenoic acid (DHA) (blue) at the 3’-termini of the passenger strand. (B) Confocal images at various incubation times (1, 4, 24 and 72 h) when DHA-siRNA and Chol-siRNA conjugates were incubated in the presence of neurons. (C) Reduction of Mtt mRNA expression mediated by DHA-siRNA and Chol-siRNA conjugates. Adapted with permission from ref. [126]. Copyright 2016, Nature Publishing Group.