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. 2018 Feb 6;9(2):74. doi: 10.3390/genes9020074

Figure 6.

Figure 6

(A) Chemical structure of Chol-siRNA conjugate containing the hydrophobic residue at the 5’-termini of the siRNA passenger strand. (B) Dynamic light scattering (DLS) of EVs alone and in the presence of Chol-siRNA conjugate. (C) Dose-response at several concentrations of EVs:siRNA (100, 200, 300, 400 and 600 nM) targeting HuR mRNA expression. (D) Evaluation of silencing process during time (24, 48, 72 and 168 h). * represents significant values of Chol-siRNA conjugate when compared to negative controls (untreated cells). Adapted with permission from ref. [133]. Copyright 2017, The American Society of Gene and Cell Therapy.