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(A) Design of aptamer-siRNA chimeras targeting SLUG and NRP1 genes. (B,C) Inhibition of gene expression mediated by aptamer-siRNA chimeras targeting SLUG (B) and NRP1 (C) mRNA expressions. * represents significant values of the siRNA nanostructure when compared to untreated cells. Adapted with permission from ref. [156]. Copyright 2014, Elsevier.
