Table 1.
Upstream regulators of selected modules predicted by IPA.
| Module | Upstream Regulator | Type | p Value of Overlap | Target Molecules in Dataset |
|---|---|---|---|---|
| turquoise | MYC | transcription regulator | 3.94 × 10−10 | CCNB1, CCNB2, CDC20, CDK1, MCM6 |
| MED1 | transcription regulator | 1.06 × 10−9 | BIRC5, CCNB1, CDC20, CDK1, CDK4, CENPA | |
| FOXM1 | transcription regulator | 0.000308 | CCNB2, CDC20 | |
| ATP7B | transporter | 0.000373 | CDC20, PTTG1, TRIP13 | |
| CNR1 | g-protein coupled receptor | 0.00157 | CCNB2, CDK1 | |
| PPARA | ligand-dependent nuclear receptor | 0.00521 | CCNB1, CDK1, CDK4, H2AFZ, TOP2A | |
| TOB1 | transcription regulator | 0.00538 | HJURP, SPDL1 | |
| brown | NFE2L2 | transcription regulator | 0.00662 | ARF1, HSP90AB1, PSMA1, PSMC3, STIP1, TMED2 |
| LMF1 | other | 0.00911 | CANX | |
| mir-451 | microRNA | 0.00911 | YWHAZ | |
| orange | LEP | growth factor | 0.00714 | ACADM, EPHX2, LIPA, UGP2 |
| PLG | peptidase | 0.00787 | CLIC4, STAB2 | |
| yellow | PPARA | ligand-dependent nuclear receptor | 7.66 × 10−8 | ACAA1, ALDH2, ALDOB, C8A, CAT, CYP2B6, CYP2C8, CYP4A11, GPD1, GSTZ1, HPX, SCP2 |
| GPD1 | enzyme | 0.00000244 | C8A, CYP2B6, CYP2C8, CYP39A1, CYP4A22, F11 | |
| SLC25A13 | transporter | 0.00000244 | C8A, CYP2B6, CYP2C8, CYP39A1, CYP4A22, F11 | |
| FECH | enzyme | 0.0000416 | CYP2B6, CYP2C8, CYP4A11, SLC10A1 | |
| RORC | ligand-dependent nuclear receptor | 0.0000458 | CYP2A6 (includes others), CYP2B6, CYP2C8, CYP39A1, CYP4A11, RDH16 | |
| RORA | ligand-dependent nuclear receptor | 0.0000485 | CYP2A6 (includes others), CYP2B6, CYP2C8, CYP39A1, CYP4A11, RDH16 | |
| LEP | growth factor | 0.0000887 | ALDOB, CYP2C8, CYP4A11, PEMT, SCP2, SLC27A5 | |
| EHHADH | enzyme | 0.000106 | ACAA1, CYP4A11, SCP2 | |
| HSD17B4 | enzyme | 0.000106 | ACAA1, CYP4A11, SCP2 | |
| ACOX1 | enzyme | 0.000492 | ACAA1, CAT, CYP4A11 | |
| POR | enzyme | 0.000531 | CYP2A6 (includes others), CYP2B6, CYP2C8, CYP39A1, CYP4A11 | |
| TCF7L2 | transcription regulator | 0.00056 | ACAA1, CYP2C8, GYS2 | |
| AHR | ligand-dependent nuclear receptor | 0.000667 | ALDH2, CYP2B6, CYP2C8, RDH16, SLC22A7 | |
| NR1H4 | ligand-dependent nuclear receptor | 0.000878 | CYP2B6, LCAT, NR1I2, SLC10A1 | |
| HNF4A | transcription regulator | 0.0011 | CAT, HPX, NR1I2, SCP2, SLC10A1 | |
| ZBTB20 | transcription regulator | 0.00172 | CYP2B6, CYP2C8, GHR | |
| NR1I3 | ligand-dependent nuclear receptor | 0.00186 | CYP2A6 (includes others), CYP2B6, CYP2C8, CYP39A1 | |
| STAT1 | transcription regulator | 0.00344 | CYP2C8, CYP4A11 | |
| STAT6 | transcription regulator | 0.004 | CIDEB, CYP4A11 | |
| ABCC4 | transporter | 0.00687 | CYP2B6 | |
| IL25 | cytokine | 0.00687 | CIDEB | |
| TERC | other | 0.00894 | CYP2C8, CYP4A11 |