Figure 4.

pCa-force relations in skinned fibre bundles indicate significant changes in Ca²⁺ sensitivity. (A–B) Expression of ssTnI in the presence of Tm54 mutations (DTG) caused an increase in the myofilament Ca²⁺ (pCa₅₀) sensitivity. (C) Hill coefficient and (D) Maximal tension (F_max). Data are presented as mean ± SE; P < 0.05. *Significantly different from NTG, †significantly different from DTG, ‡significantly different from Tm54 based on post-hoc multiple comparison analysis (Newman-Keuls test). n = 8 per group.