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. 2017 Jul 20;113(14):1753–1762. doi: 10.1093/cvr/cvx115

Figure 5.

Figure 5

Mmp2 gene deletion blunted Ang II-induced signalling in vascular smooth muscle cells (VSMCs). The level of phosphorylation of epidermal growth factor receptor (EGFR) and of p44/42 mitogen-activated protein kinase (extracellular-signal-regulated kinase 1/2, ERK1/2) in VSMCs from small mesenteric arteries cultured in presence or absence of Ang II for 5 min were determined by western blot. Representative western blots of phosphorylated (p) and total EGFR and ERK1/2 (A) and corresponding dot plots (B) are represented. Values are means ± SEM, number of sample per group for p-EGFR/EGFR: WT = 6, Mmp2-/- = 7 and other groups = 5, and for p-ERK1/2/ERK1/2: eight per group. Data were analysed using two-way ANOVA followed by a Student–Newman–Keuls post hoc test. *P < 0.01 and **P < 0.001 and vs. their respective controls and †P < 0.01 and vs. ††P < 0.01 WT + Ang II.