Figure 3.

Decompensated function in 11–12 month-old E143K mice. Heart morphology and function were assessed in E143K vs. WT mice by echocardiography (A) and invasive haemodynamics (B). Note a more pronounced phenotype in male vs. female E143K compared with WT mice. Data expressed as mean ± SEM; t-test, *P < 0.05 vs. WT. Abbreviations as in Figure 2.