Table 4.
Type III tests of fixed effects (n=41)
|
|
Drug F (p)a | Minutes F (p)b | Drug*Minutes F (p)b |
|---|---|---|---|
| Constructs | |||
|
|
|
|
|
| Depressed Mood | 43.40 (<.0001) | 3.30 (.004) | 2.00 (.07) |
|
|
|
|
|
| Tension | 41.22 (<.0001) | 9.02 (<.0001) | 3.31 (.004) |
|
|
|
|
|
| Negative Cognition | 48.90 (<.0001) | 9.8 (<.0001) | 3.08 (.006) |
|
|
|
|
|
| Impaired Sleep | 13.19 (.0009) | 1.45 (.194) | 0.30 (.94) |
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|
|
|
|
| Suicidal Thoughts | 47.96 (<.0001) | 9.42 (<.0001) | 4.32 (.0003) |
|
|
|
|
|
| Reduced Appetite | 0.59 (.44) | 2.78 (.01) | 7.33 (<.0001) |
|
|
|
|
|
| Anhedonia | 18.07 (.0001) | 1.99 (.07) | 0.71 (.64) |
|
|
|
|
|
| Amotivation | 38.50 (<.0001) | 3.83 (.001) | 0.55 (.77) |
|
|
|
|
|
| Conventional Scores | |||
|
|
|
|
|
| BDI Total | 44.19 (<.0001) | 8.10 (<.0001) | 1.38 (.22) |
|
|
|
|
|
| HAM-D Total | 36.09 (<.0001) | 4.68 (.0001) | 1.22 (.30) |
|
|
|
|
|
| MADRS Total | 47.37 (<.0001) | 3.90 (.0009) | 1.62 (.14) |
|
|
|
|
|
| SHAPS Total | 15.41 (.0003) | 2.32 (.03) | 0.77 (.60) |
|
|
|
|
|
a
Numerator DF was 1, denominator DF ranged from 31.3 to 57.2.
b
Numerator DF was 6, denominator DF ranged from 290 to 384.
Note: BDI: Beck Depression Inventory; HAM-D: Hamilton Rating Scale for Depression; MADRS: Montgomery-Asberg Depression Rating Scale; SHAPS: Snaith Hamilton Pleasure Scale; DF: degrees of freedom. Results of a mixed model with compound symmetry covariance structure for repeated measures, random subject effect, and Satterthwaite’s approximation for degrees of freedom. Period-specific baseline was entered as a covariate.