. 2018 Jan 23;10(2):112. doi: 10.3390/nu10020112

Table 3.

Dose-response meta-analysis of prospective cohort studies on coffee consumption and breast cancer risk.

	No. of Datasets (No. of Studies)	Coffee Intake (Cups/Day)								I² (%)	P_{heterogeneity}	P_{non-linearity}
	No. of Datasets (No. of Studies)	0	1	2	3	4	5	6	7
Total
Non-linear	13 (13)	Ref.	0.98 (0.94, 1.03)	0.97 (0.88, 1.06)	0.96 (0.84, 1.11)	0.96 (0.79, 1.16)	0.95 (0.75, 1.22)	0.95 (0.71, 1.28)	0.95 (0.67, 1.34)	-	0.69	0.52
Linear	13 (13)	Ref.	0.99 (0.98, 1.00)	0.98 (0.96, 0.99)	0.97 (0.94, 0.99)	0.96 (0.93, 0.99)	0.95 (0.91, 0.98)	0.93 (0.89, 0.98)	0.92 (0.88, 0.98)	-	0.58	NA
Postmenopausal
Non-linear	6 (6)	Ref.	1.00 (0.96, 1.04)	0.99 (0.93, 1.05)	0.96 (0.89, 1.03)	0.92 (0.84, 1.00)	0.88 (0.79, 0.99)	0.85 (0.74, 0.97)	0.82 (0.69, 0.96)	0	0.71	0.14
Linear	6 (6)	Ref.	0.97 (0.95, 1.00)	0.95 (0.90, 1.00)	0.92 (0.86, 1.00)	0.90 (0.82, 0.99)	0.88 (0.78, 0.99)	0.85 (0.74, 0.99)	0.83 (0.70, 0.99)	39.6	0.14	NA
BMI > 25 kg/m²
Non-linear	5 (5)	Ref.	0.98 (0.91, 1.06)	0.97 (0.86, 1.10)	0.97 (0.84, 1.12)	0.97 (0.82, 1.14)	0.97 (0.80, 1.18)	0.97 (0.76, 1.24)	0.97 (0.72, 1.30)	10.1	0.35	0,77
Linear	5 (5)	Ref.	0.99 (0.96, 1.02)	0.98 (0.92, 1.05)	0.97 (0.88, 1.08)	0.96 (0.84, 1.10)	0.95 (0.81, 1.13)	0.95 (0.77, 1.16)	0.94 (0.74, 1.19)	39	0.16
ER-/PR-
Non-linear	5 (4)	Ref.	0.93 (0.84, 1.04)	0.9 (0.76, 1.07)	0.91 (0.77, 1.08)	0.94 (0.79, 1.11)	0.97 (0.79, 1.19)	1.00 (0.77, 1.30)	1.04 (0.75, 1.43)	0	0.88	0.25
Linear	5 (4)	Ref.	0.99 (0.95, 1.03)	0.98 (0.91, 1.06)	0.97 (0.86, 1.10)	0.97 (0.82, 1.13)	0.96 (0.78, 1.17)	0.95 (0.75, 1.20)	0.94 (0.71, 1.24)	66.3	0.43	NA