Table 2.

Voxel-based morphometry assessment of grey and white matter at PND 61 comparing pigs from differing early-life iron status ¹.

			Cluster Level		Peak Level		Local Maxima Coordinates 3
Tissue	Comparison	Anatomic Region 2	Number of Voxels	p-Value	p-Value	Pseudo-t	X	Y	Z
Grey	CONT > ID	Right Cortex	2045	<0.001	<0.001	7.31	14.0	0.0	−12.6
		Right Cortex			<0.001	5.32	18.9	−13.3	−8.4
		Cerebellum	2772	<0.001	<0.001	6.92	−10.5	−25.2	0.0
		Cerebellum			<0.001	5.98	−2.8	−27.3	2.8
		Left Cortex			<0.001	5.16	−10.5	−16.8	5.6
		Right Cortex	443	0.004	<0.001	5.98	11.9	−15.4	7.7
		Cerebellum	997	<0.001	<0.001	5.55	−18.9	−18.9	−7.7
		Cerebellum	251	0.023	<0.001	5.54	9.1	−9.8	−2.1
		Right Hippocampus			<0.001	5.12	2.1	−9.1	6.3
		Left Cortex	242	0.025	<0.001	5.27	−14.0	−1.4	−3.5
		Left Cortex	204	0.037	<0.001	5.01	−13.3	−7.0	13.3
		Cerebellum	47	0.291	<0.001	4.83	11.9	−25.9	−2.8
		Thalamus	160	0.061	<0.001	4.36	0.0	10.5	0.7
		Right Cortex	79	0.175	<0.001	4.35	3.5	36.4	4.9
		Right Cortex	72	0.194	<0.001	4.15	13.3	−9.8	11.2
		Left Cortex	24	0.455	0.001	3.97	−5.6	−20.3	11.9
		Left Cortex	42	0.318	0.001	3.97	−2.1	33.6	5.6
		Caudate	21	0.486	0.001	3.81	2.1	18.2	2.8
Grey	CONT <ID	Right Cortex	419	0.005	<0.001	5.51	22.4	0.7	10.5
		Left Cortex	57	0.246	<0.001	4.45	−19.6	4.2	7.0
		Right Cortex	35	0.363	<0.001	4.34	18.2	16.1	12.6
White	CONT > ID	Right Hippocampus	234	0.022	<0.001	6.37	8.4	−2.1	8.4
		Right Cortex	629	0.001	<0.001	6.19	10.5	−16.8	9.1
		Right Cortex			<0.001	4.61	15.4	−9.8	13.3
		Right Cortex	378	0.005	<0.001	5.85	20.3	−7.0	4.2
		Left Cortex	653	0.001	<0.001	5.26	−14.0	−15.4	9.1
		Cerebellum			<0.001	4.26	−18.9	−16.1	0.7
		Internal Capsule	51	0.252	<0.001	4.48	−11.2	−5.6	7.7
		Left Hippocampus	61	0.212	<0.001	4.42	−7.0	−1.4	7.0
		Left Cortex	26	0.415	<0.001	4.07	−18.9	−7.7	11.2
		Internal Capsule	40	0.310	0.001	4.00	−8.4	20.3	3.5
White	CONT < ID	None	-	-	-	-	-	-	-

¹ Voxel-based morphometry analysis of gray and white matter differences in the CONT and ID pig brains at PND 61. A threshold of p <0.001 and minimum cluster size of 20 voxels were used to determine p-uncorrected values listed in the table. Abbreviations: control (CONT), iron deficient (ID). ² Brain regions based on visual inspection of the cluster location and cross-referenced with the Piglet Brain Atlas [29]. ³ Local maxima coordinates: X increases from left (−) to right (+), Y increases from posterior (−) to anterior (+), and Z increases from inferior (−) to superior (+).