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. 2018 Jan 31;10(2):159. doi: 10.3390/nu10020159

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Metabolic characterization of female Scly^−/− mice on a Se deficient diet. For metabolic characterization, WT: n = 4, Scly^−/−: n = 7. Unless otherwise indicated, mice were 22-weeks-old. (a) Body weight of female WT (FWT) and Scly^−/− mice at the indicated time points (two-way ANOVA: time F_3,27 = 99.33, p < 0.0001, genotype F_1,27 = 25.38, p = 0.0007, interaction F_3,27 = 13.87, p < 0.0001); (b) gonadal WAT (gWAT) expressed as % body weight; (c) glucose tolerance test in 20-week-old mice; (d) area under the curve (AUC); (e) fasting serum insulin. Twenty-two-week old mice were insulin challenged and hepatic expression of (f) pAkt (WT: n = 4, Scly^−/−: n = 7); (g) pAMPK (n = 4/group); and (h) pACC1 (n = 4/group) was measured. Phosphorylated proteins were normalized to total protein levels. All data are represented as means ± S.E.M (* p < 0.05, *** p < 0.001).