Table 2.
Association of vitamin D-binding protein genetic polymorphisms and serum 25OHD levels by race/ethnicity.
| Race/Ethnicity | SNP | n | Reference Allele | Variant Allele | Variant Allele Frequency | β Estimate * | Change in Total 25OHD Level Per Variant Allele Copy (95% CI), nmol/L | p |
|---|---|---|---|---|---|---|---|---|
| Black | rs7041 | 247 | C | A | 0.828 | −0.1136 | −5.5 (−11.9 to 0.2) | 0.0573 |
| Hispanic | rs7041 | 380 | C | A | 0.483 | −0.0492 | −2.7 (−5.9 to 0.3) | 0.0757 |
| White | rs7041 | 514 | C | A | 0.443 | −0.0813 | −5.9 (−9.3 to −2.7) | 0.0002 |
| Black | rs4588 | 247 | G | T | 0.119 | −0.2148 | −8.9 (−13.5 to −3.7) | 0.0014 |
| Hispanic | rs4588 | 380 | G | T | 0.230 | −0.0836 | −4.4 (−7.6 to −0.9) | 0.0135 |
| White | rs4588 | 514 | G | T | 0.290 | −0.1160 | −7.7 (−10.5 to −4.7) | <0.0001 |
25OHD = 25-hyrdoxyvitamin D, CI = confidence intervals; * adjusted for age, sex, BMI, season of 25OHD measurement, smoking, genetic ancestry and case status.