Table A1.
Sensitivity analysis: Association of Vitamin D-binding protein Genetic Polymorphisms and serum 25OHD levels by race/ethnicity excluding subjects using vitamin-D supplements at the time of 25OHD measurement.
| Race/Ethnicity | SNP | n | Reference Allele | Variant Allele | Variant Allele Frequency | Β Estimate * | Change in Total 25OHD Level Per Variant Allele Copy (95% CI), nmol/L | p |
|---|---|---|---|---|---|---|---|---|
| Black | rs7041 | 217 | C | A | 0.825 | −0.1322 | −6.3 (−13.1 to −0.4) | 0.0358 |
| Hispanic | rs7041 | 347 | C | A | 0.488 | −0.0490 | −2.8 (−5.9 to 0.3) | 0.0733 |
| White | rs7041 | 433 | C | A | 0.441 | −0.0675 | −4.9 (−8.4 to −1.5) | 0.0044 |
| Black | rs4588 | 217 | G | T | 0.124 | −0.2290 | −9.2 (−13.7 to −4.1) | 0.0009 |
| Hispanic | rs4588 | 347 | G | T | 0.232 | −0.0933 | −4.9 (−8.1 to −1.5) | 0.0052 |
| White | rs4588 | 433 | G | T | 0.281 | −0.1191 | −7.9 (−10.9 to −4.6) | <0.0001 |
25OHD = 25-hyrdoxyvitamin D, CI = confidence intervals; * adjusted for age, sex, BMI, season of 25OHD measurement, smoking, genetic ancestry and case status.