Table 2.

Selected KEGG biological pathways potentially affected by (a) miRNAs down-regulated; and (b) miRNAs up-regulated in the presence of vitamin C in human bone marrow stromal cells.

(a)
KEGG Pathway	p-Value	Number of Genes Involved	Number of miRNAs Involved
Prion diseases	4.07 × 10−10	7	7
Morphine addiction	4.80 × 10−5	32	17
Amino sugar and nucleotide sugar metabolism	0.002142	16	11
Thyroid hormone signaling pathway	0.002958	37	17
Cell adhesion molecules (CAMs)	0.006179	43	16
Endocytosis	0.009192	63	18
Oxytocin signaling pathway	0.011941	53	21
Melanogenesis	0.013774	35	17
MAPK signaling pathway	0.013774	77	22
GABAergic synapse	0.02274	32	18
Vasopressin-regulated water reabsorption	0.035605	16	11
Adrenergic signaling in cardiomyocytes	0.035605	48	22
Glutamatergic synapse	0.03746	34	13
Biosynthesis of unsaturated fatty acids	0.040121	7	5
Circadian entrainment	0.046058	37	16
(b)
KEGG Pathway	p-Value	Number of Genes Involved	Number of miRNAs Involved
Mucin type O-Glycan biosynthesis	1.69 × 10−11	11	7
Fatty acid biosynthesis	1.86 × 10−8	1	1
Glycosphingolipid biosynthesis-lacto and neolacto series	6.27 × 10−5	9	8
Fatty acid metabolism	0.000184	7	6
Adherens junction	0.000623	25	18
Biotin metabolism	0.010804	1	1
Arrhythmogenic right ventricular cardiomyopathy	0.014001	21	18
Caffeine metabolism	0.027365	2	2
Thyroid hormone signaling pathway	0.027365	32	21