Figure 5.

ZIP7 is essential for dermis formation. (a) Five-week-old female wild-type (WT) and Zip7^Col1 mice. (b) The thickness of the Azan-stained Zip7^Col1 dermis is reduced. M, muscle; S, Subcutis. (c) Models for the involvement of ZIP7 in ER function. When ZIP7 is dysregulated (right), the luminal zinc level is elevated, which would induce zinc-dependent aggregation of PDIs. Therefore, protein folding and disulfide bond formation would proceed aberrantly, leading to unfolded protein responses. ER, endoplasmic reticulum; KO, knockout; PDI, protein disulfide isomerase; UPR, unfolded protein response. Modified from Bin et al. [37].